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KMID : 0361020090520070594
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Korean Journal of Otolaryngology - Head and Neck Surgery
2009 Volume.52 No. 7 p.594 ~ p.598
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Immunoglobulin E and Transcription Factor in Adenoid of Children with Allergy
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Eun Young-Gyu
Yeo Seung-Geun
Jung Hoon
Chung Dae-Han
Kim Myung-Gu
Byun Jae-Yong
Park Moon-Suh
Cha Chang-Il
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Abstract
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Background and Objectives : Immunoglobulin E (IgE) production in adenoid has been debated and the role of adenoid in development of allergy remains largely unknown. To examine the production of local IgE in adenoid involved with IgE-mediated sensitization, we evaluated IgE production and the expression of the transcription factor B cell leukemia/lymphoma-6 (BCL-6) and B lymphocyte inducer of maturation program 1 (Blimp-1) in adenoids.
Subjects and Method : Ten children with allergic rhinitis (AR) and ten children without any history of AR were enrolled. Immunohistochemical studies of adenoid for IgE, BCL-6 and Blimp-1 were performed.
Results: IgE was stained mainly in the germinal center and submucosal area and the staining scores of antibody to IgE did not differ signigicantly between children with AR and control. BCL- 6 was mainly stained in mucosa and germinal center and Blimp-1 in mucosa. The scores of antibody to BCL-6 and Blimp-1 in children with AR and control did not show significant differences.
Conclusion: We found that allergic rhinitis was not involved in the production of IgE nor the expression of the transcription factor BCL-6 and Blimp-1 in adenoid.
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KEYWORD
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Adenoid, IgE, BCL-6, Blimp-1, Allergy
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